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Home / Proteins & Peptide

Recombinant Human IKK alpha (N-GST tag)

SKU : BHP10900365

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500176
Description	IKKa is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex . IKKa is an essential regulator of NF-kappa-B-dependent gene expression through control of promoter-associated histone phosphorylation after cytokine exposure . IKKa is a critical component of the cytoplasmic transductional-transcriptional processor leading to induction of IFNa production. IKKa is also involved in the epidermis where it antagonizes mitogenic and angiogenic signals and represses tumor progression and metastases.
Alternative Names	NFKBIKA ; IKK-alpha ; CHUK ; IKK1 ; IKBKA ; TCF16
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of IKKa was determined to be 2.5 nmol /min/mg as per activity assay protocol.

Weight	114.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900365	Z500176	10µg	$361.11		Add to Cart

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