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Home / Proteins & Peptide

Recombinant Human IFNGR1 Protein (His Tag)(Active)

SKU : BHP10303030

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031670
Description	A DNA sequence encoding the extracellular domain (Met 1-Gly 245) of human IFN-gammaR1 pre-protein (NP_000407.1) was expressed, fused with a polyhistidine tag at the C-terminus.
Alternative Names	CD119;IFNGR;IMD27A;IMD27B;Interferon gamma receptor 1;IFNGR1
Reconstitution	Please refer to the printed manual for detailed information.
Background	The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD119 (cluster of differentiation 119), also known as IFNGR1 ( interferon gamma receptor 1), is part of the heterodimeric gamma interferon receptor which consists of IFNGR1 (CD119) and IFNGR2. The IFNGR1 gene encodes the ligand-binding chain (alpha) of the interteron receptor while IFNGR gene encodes the non-ligand binding partner. The ability of the interferon-γ was achieved through binding to the interferon receptor CD119. After binding, the products of activated T-lymphocytes interferon-γ exerts antiviral activity, growth inhibitory effect, and several immune- regulatory activities on a variety of cell types.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_000407.1
Endotoxin Level	< 1.0 EU per ug of the protein as determined by the LAL method.
Bioactivity	Measured by its ability to inhibit rhIFNgamma mediated protection of WISH cells infected with vesicular stomatitis virus(VSV).The ED50 for this effect is typically 2-8 ug/mL.
Mol Weight	27.3 kDa
Mw(kda)	27.3 kDa

Sequence Info	Met 1-Gly 245

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 97 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303030	PKSH031670	100ug	$486		Add to Cart

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