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Home / Proteins & Peptide

Recombinant Human ICAM-2/CD102 Protein (His Tag)(Active)

SKU : BHP10303034

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031677
Description	A DNA sequence encoding the extracellular domain (Met 1-Gln 223) of human ICAM2 (NP_000864.2) was fused with a polyhistidine tag at the C-terminus.
Alternative Names	Intercellular Adhesion Molecule 2; ICAM-2; CD102; ICAM2
Reconstitution	Please refer to the printed manual for detailed information.
Background	Intercellular adhesion molecule 2 (ICAM-2, CD102), belongs to the ICAM family consisting of three members identified as ligands for integrin receptors. It is a type I transmembrane glycoprotein with two Ig-like C2-type domains, and binds to the leukocyte integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). As a second ligand of leukocyte function-associated antigen-1, ICAM-2 functions as a costimulatory molecule for effector cells. ICAM-2 is mainly expressed on vascular endothelial and hematopoietic cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relation with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in diagnosis of trichinosis recent infections, and in monitoring the prognosis and response to treatment.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile PBS, pH 7.5
Host	HEK293 Cells
Accession Number	NP_000864.2
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells. When cells are added to ICAM2-coated plates (12.5 ug/ml, 100 ul/well), approximately 35 %-45% will adhere specifically.
Mol Weight	24 kDa
Mw(kda)	24 kDa

Sequence Info	Met 1-Gln 223

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 97 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303034	PKSH031677	100ug	$855		Add to Cart

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