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Home / Proteins & Peptide

Recombinant Human IA2/PTPRN Protein (aa 607-Asn686 & aa 795-888, His Tag)

SKU : BHP10303602

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH032555
Description	Recombinant Human Islet Cell Antigen 2/Protein Tyrosine Phosphatase Receptor-type N is produced by our E.coli expression system and the target gene encoding Gln607-Asn686&Trp795-Leu888 is expressed with a 6His tag at the N-terminus.
Alternative Names	Receptor-type tyrosine-protein phosphatase-like N; R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2; PTPRN; ICA3; ICA512
Reconstitution	Please refer to the printed manual for detailed information.
Background	Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain; is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules; such as their biogenesis; trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity; may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera; and thus may be a potential target of autoimmunity in diabetes mellitus.
Reactivity	Human
Tag	N-6His
Formulation	Supplied as a 0.2 um filtered solution of PBS; pH7.4.
Host	E.coli
Accession Number	Q16849
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	22.9 kDa
Mw(kda)	22.9 kDa

Sequence Info	Gln607-Asn686&Trp795-Leu888

Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stotage Note	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Purity	> 90 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303602	PKSH032555	10ug	$223		Add to Cart
BHP10303602	PKSH032555	50ug	$593		Add to Cart

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