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Home / Proteins & Peptide

Recombinant Human Hydroxymethylglutaryl-CoA lyase, mitochondrial(HMGCL)

SKU : BHP10503723

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP010563HU
Alternative Names	3-hydroxy-3-methylglutarate-CoA lyase
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Hydroxymethylglutaryl-CoA lyase, mitochondrial; Short name= HL; Short name= HMG-CoA lyase; EC= 4.1.3.4; Alternative name(s): 3-hydroxy-3-methylglutarate-CoA lyase
Expression Region	1-325aa
Mol Weight	58.5kDa
Nature	recombinant
Protein Description	Full Length

Involvement In Disease	3-hydroxy-3-methylglutaryl-CoA lyase deficiency (HMGCLD)
Subcellular Location	Mitochondrion matrix, Peroxisome
Uniprot	P35914, P35914
Database Links	HGNC:5005 OMIM:246450 KEGG:hsa:3155 STRING:9606.ENSP00000363614 UniGene:Hs.533444
Function	Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism.
Protein Families	HMG-CoA lyase family
Research Area	Signal Transduction
Tissue Specificity	Highest expression in liver. Expressed in pancreas, kidney, intestine, testis, fibroblasts and lymphoblasts. Very low expression in brain and skeletal muscle. The relative expression of isoform 2 (at mRNA level) is highest in heart (30%), skeletal muscle
Weight	63.475kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503723	CSB-EP010563HU	1mg	$1812		Add to Cart
BHP10503723	CSB-EP010563HU	100ug	$419		Add to Cart
BHP10503723	CSB-EP010563HU	20ug	$224		Add to Cart

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