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Home / Proteins & Peptide

Recombinant Human HGK (N-GST tag)

SKU : BHP10900070

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500167
Description	HGK is the mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) and a member of the serine/threonine protein kinase family. HGK has been shown to specifically activate MAPK8/JNK . The activation of MAPK8 by HGK can be inhibited by dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggest that this kinase functions through the MAP3K7-MAP2K4-MAP2K7 kinase cascade and mediates TNF-a signaling. HGK-dependent signaling inhibits PPAR?-responsive gene expression, adipogenesis, and insulin-stimulated glucose transport .
Alternative Names	FLH21957 ; FLJ10410 ; FLJ20373 ; FLJ90111 ; KIAA0687 ; MAP4K4 ; NIK
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of HGK was determined to be 54 nmol /min/mg as per activity assay protocol.

Weight	64.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900070	Z500167	10µg	$361.11		Add to Cart

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