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Home / Proteins & Peptide

Recombinant Human HGFR/c-MET Protein (Fc Tag)(Active)

SKU : BHP10303586

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH032536
Description	Recombinant Human Hepatocyte Growth Factor Receptor is produced by our Mammalian expression system and the target gene encoding Glu25-Thr932 is expressed with a Fc tag at the C-terminus.
Alternative Names	Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met; MET
Reconstitution	Please refer to the printed manual for detailed information.
Background	Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular alpha chain and a 145 kDa transmembrane beta chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain; consist of secreted extracellular domains; or are deficient in proteolytic separation of the alpha and beta chains. The sema domain; which is formed by both alpha and beta chains of HGF R; mediates both ligand binding and receptor dimerization. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells.
Reactivity	Human
Tag	C-Fc
Formulation	Lyophilized from a 0.2 um filtered solution of PBS; pH7.4.
Host	Human Cells
Accession Number	P08581
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Immobilized HGF R-Fc at 2ug/ml(100 ul/well) can bind Human HGF-His(Cat: PKSH032538). The ED50 of HGF R-Fc is 0.82 ug/mL
Mol Weight	128.4 kDa
Mw(kda)	128.4 kDa

Sequence Info	Glu25-Thr932

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303586	PKSH032536	10ug	$62		Add to Cart
BHP10303586	PKSH032536	50ug	-		Add to Cart

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