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Home / Proteins & Peptide

Recombinant Human HGF

SKU : BHP10900738

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z102777
Description	Hepatocyte growth factor (HGF) is a multifunctional cytokine that was originally described as a mesenchymal-derived factor that regulates cell growth, cell motility, morphogenesis and angiogenesis through activation of its receptor, the transmembrane tyrosine kinase encoded by the c-Met proto-oncogene. HGF and c-Met are often co-expressed or over-expressed in a variety of human malignancies including glioblastoma and medullablastoma. The multifunctional effects of HGF: c-Met signaling in tumor cells are mediated by a network of signal transduction pathways including mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K). HGF consists of two subunits held by a disulfide bond. The alpha subunit (69 kDa) has a length of 440 amino acids and the beta subunit (34 kDa) has a length of 234 amino acids. The beta chain of the factor shows approximately 38% homology at the protein level to the serine protease domain of plasminogen. Recombinant HGF expressed in human 293 cells and has a molecular mass of 70 kDa, lower compared to the Molecular mass for this cytokine expressed in CHO cells which emphasizes the difference in post translational modifications.
Alternative Names	Hepatopoietin-A ; HPTA ; Scatter factor ; SFRecombinant Human Hepatocyte Growth Factor (HGF) ; HGF
Quantity	1.0 mg
Regulatory	RUO
Source	HEK293
Host	Human
Endotoxin Level	<1 EU/µg of recombinant protein as determined by the LAL method
Biological Activity Comment	The EC(50) as determined by the dose-dependent stimulation of the proliferation of the monkey epithelial cell line 4MBr-5 was found to be ≤ 20 ng/mL.

Weight	70 kDa, single chain, glycosylated

Description	A quick spin of the vial followed by reconstitution in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Format	Lyophilized Powder 1x PBS
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900738	Z102777	1.0mg	$3905		Add to Cart

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