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Home / Proteins & Peptide

Recombinant Human HER4 (N-GST tag)

SKU : BHP10901230

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500166
Description	HER4 or ERBB4 is a transmembrane receptor tyrosine kinase that belongs to epidermal growth factor receptor family . Through its interaction with its activating ligand heregulin, HER4 can regulate proliferation and differentiation of cells . HER4 ectodomain is cleaved by a metalloprotease, gamma-secretase that releases the HER4 intracellular domain from the membrane and facilitates its translocation to the nucleus. The kinase activity of HER4 is both necessary and sufficient to trigger an antiproliferative response in human breast cancer cells. Increased expression of HER4 has been detected in various cancers and this usually correlates to better survival.
Alternative Names	MGC138404 ; p180erbB4 ; ERBB4
Tag	N-GST tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of HER4 was determined to be 669 nmol /min/mg as per activity assay protocol.

Weight	57.0 kDa

Format	Liquid 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10901230	Z500166	10µg	$361.11		Add to Cart

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