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Home / Proteins & Peptide

Recombinant Human Heart- and neural crest derivatives-expressed protein 2(HAND2)

SKU : BHP10503703

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP010126HU
Alternative Names	Class A basic helix-loop-helix protein 26
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3'
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Heart- and neural crest derivatives-expressed protein 2Alternative name(s): Class A basic helix-loop-helix protein 26 Short name= bHLHa26 Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed pro
Expression Region	1-180aa
Mol Weight	47.3kDa
Nature	recombinant
Protein Description	Full Length of Isoform 2

Subcellular Location	Nucleus
Uniprot	P61296, P61296
Database Links	HGNC:4808 OMIM:602407 KEGG:hsa:9464 STRING:9606.ENSP00000352565 UniGene:Hs.388245
Function	Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Heart.
Weight	47.38kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503703	CSB-EP010126HU	1mg	$2466		Add to Cart
BHP10503703	CSB-EP010126HU	100ug	$578		Add to Cart
BHP10503703	CSB-EP010126HU	20ug	$306		Add to Cart

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