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Home / Proteins & Peptide

Recombinant Human Guanine nucleotide-binding protein-like 3-like protein(GNL3L)

SKU : BHP10501535

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP865150HU
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-582aa
Mol Weight	81.6kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Nucleus, nucleolus
Uniprot	Q9NVN8, Q9NVN8
Database Links	HGNC:25553 OMIM:300873 KEGG:hsa:54552 STRING:9606.ENSP00000338573 UniGene:Hs.654677
Function	Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Protein Families	TRAFAC class YlqF/YawG GTPase family
Research Area	Others
Weight	81.53kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501535	CSB-EP865150HU	1mg	$1812		Add to Cart
BHP10501535	CSB-EP865150HU	100ug	$419		Add to Cart
BHP10501535	CSB-EP865150HU	20ug	$224		Add to Cart

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