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Home / Proteins & Peptide

Recombinant Human Growth/differentiation factor 9(GDF9)

SKU : BHP10500560

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP009352HU
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	320-454aa
Mol Weight	42.5kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Involvement In Disease	Altered GDF9 function may be involved in ovarian disorders. Rare variants in GDF9 have been found in patients with premature ovarian failure and mothers of dizygotic twins.
Subcellular Location	Secreted
Uniprot	O60383, O60383
Database Links	HGNC:4224 OMIM:601918 KEGG:hsa:2661 STRING:9606.ENSP00000296875 UniGene:Hs.25022
Function	Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells.
Protein Families	TGF-beta family
Research Area	Cardiovascular
Tissue Specificity	Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level).
Weight	42.9kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500560	CSB-EP009352HU	1mg	$1812		Add to Cart
BHP10500560	CSB-EP009352HU	100ug	$419		Add to Cart
BHP10500560	CSB-EP009352HU	20ug	$224		Add to Cart

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