GRK3 or beta-adrenergic receptor kinase 2 specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. GRK3 is a member of the receptor kinase family that broadly serves to regulate receptor function . GRK3 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. GRK3 is highly expressed in lung, heart, and adipose tissue . Single nucleotide polymorphisms (SNPs) in the promoter region of GRK3 have been associated with bipolar disorder.
Alternative Names
ADRBK2 ; BARK2
Tag
N-GST tag
Quantity
10 µg
Regulatory
RUO
Source
Insect cells
Host
Human
Biological Activity Comment
The specific activity of GRK3 was determined to be 6 nmol /min/mg as per activity assay protocol.
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.