Gal-3 interacts, via its lectin domain, with glycoproteins and glycolipids on the surface of animal cells. It has been shown that nuclear Gal3 can modulate gene expression while cytosolic Gal3 can inhibit apoptosis and participate in exocytosis. Gal-3 is generally expressed by the epithelial cells of many tissues as well as by inflammatory cells. An increased level of Gal-3 expression may lead to some lymphomas, as well as thyroid and hepatic carcinomas while the down-regulation has been associated with breast and colon cancer.
Alternative Names
CBP 35 ; Galactose-specific lectin 3 ; Galactoside-binding protein ; GALBP ; L-31 ; Laminin-binding protein ; Lectin L-29 ; Mac-2 antigen ; IgE-Binding Protein ; Gal-3 ; 35 kDa lectin ; Carbohydrate-binding protein 35
Quantity
1.0 mg
Regulatory
RUO
Source
E. coli
Host
Human
Endotoxin Level
< 1.0 EU/μg of recombinant protein as determined by the LAL method.
Biological Activity Comment
Measured by its ability to agglutinate human red blood cells. The ED(50) for this effect is typically 3-10 µg/mL.
Weight
26.1 kDa
Description
Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
Format
Lyophilized PowderLyophilized from a 0.2 μm filtered solution in PBS and 2-ME with BSA as a carrier protein
Purity
>95% as determined by SDS-PAGE
Storage
The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.