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Home / Proteins & Peptide

Recombinant Human Galectin-1 (LGALS1)

SKU : BHP10901071

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z101847
Description	Galectin-1 is a member of the galectin family, and binds B-galactosidase moieties on glycoproteins or glycolipids. Galectins are primarily involved in modulation of cell-cell and cell-matrix interactions. Galectin-1 acts as a negative regulator of immunity, promoting immune suppression and lessening the inflammatory response. Galectin-1 binds CD45, CD3 and CD4, resulting in the inhibition of CD45 phosphatase dependant dephosphorylation of lyn kinase, as well as a number of other immune related receptors. Due to its function as a negative regulator of the immune response, and role inducing apoptosis in activated Th1 and Th17 cells, it is commonly found upregulated around malignant tumours. It has also been implicated as having a role in the development of immune tolerance during pregnancy, and is highly expressed at the maternal-fetal interface. As a dimer it down-regulates neutrophils by inducing exposure of phosphatidylserine, thereby marking the cell for apoptosis. It shares approximately 88% and 90% sequence similarity with mouse and rat galectin-1, respectively. Recombinant Human Galectin-1 is a 14.9kDa protein.
Alternative Names	14 kDa lectin ; Galaptin ; HBL ; HPL ; Lactose-binding lectin 1 ; Lectin galactoside-binding soluble 1 ; Putative MAPK-activating protein PM12 ; S-Lac lectin 1 ; Beta-Galactoside-Binding Lectin L-14-I ; Gal-1 ; 14 kDa laminin-binding protein ; HLBP14
Quantity	100 µg
Regulatory	RUO
Source	E. coli
Host	Human
Endotoxin Level	<1.0 EU/μg of recombinant protein as determined by the LAL method
Biological Activity Comment	Measured by its ability to agglutinate human red blood cells. The ED(50) for this effect is typically 0.53 µg/mL.

Weight	14.9 kDa

Description	Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin
Format	Lyophilized Powder Lyophilized from a 0.2 μm filtered solution in PBS and 2-ME with BSA as a carrier protein.
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months, with a carrier protein without detectable loss of activity.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10901071	Z101847	100µg	$244.44		Add to Cart

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