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Home / Proteins & Peptide

Recombinant Human G-protein coupled receptor 161(GPR161),partial

SKU : BHP10501785

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-RP041144h
Alternative Names	G-protein coupled receptor RE2
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is roved from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown .
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-28aa
Mol Weight	30.0kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Cell projection, cilium membrane, Multi-pass membrane protein, Cell membrane, Multi-pass membrane protein
Uniprot	Q8N6U8, Q8N6U8
Database Links	HGNC:23694 OMIM:612250 KEGG:hsa:23432 STRING:9606.ENSP00000271357 UniGene:Hs.271809
Function	Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
Pathway	Hedgehog signaling pathway
Protein Families	G-protein coupled receptor 1 family
Research Area	Signal Transduction
Weight	30.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501785	CSB-RP041144h	1mg	$1812		Add to Cart
BHP10501785	CSB-RP041144h	100ug	$419		Add to Cart
BHP10501785	CSB-RP041144h	20ug	$224		Add to Cart

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