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Recombinant Human Forkhead box protein O3(FOXO3),partial

SKU : BHP10505514

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP008836HU1
Description	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Alternative Names	AF6q21 protein Forkhead in rhabdomyosarcoma-like 1 FKHRL1 FOXO3A
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	AF6q21 protein; Forkhead in rhabdomyosarcoma-like 1; FKHRL1 FOXO3A
Expression Region	372-673aa
Mol Weight	48.1 kDa
Nature	Recombinant
Protein Description	Partial

Involvement In Disease	A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with KMT2A/MLL1.
Subcellular Location	Cytoplasm, cytosol, Nucleus
Uniprot	O43524, O43524
Database Links	HGNC:3821 OMIM:602681 KEGG:hsa:2309 STRING:9606.ENSP00000339527 UniGene:Hs.220950
Function	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC
Pathway	Chemokine signaling pathway; PI3K-Akt signaling pathway; Cellular senescence; MAPK Erk pathway; AMPK signaling; FoxO signaling pathway; Neurotrophin signaling pathway
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Ubiquitous.
Weight	48.1 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 85% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer，50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505514	CSB-EP008836HU1	1mg	$2466		Add to Cart
BHP10505514	CSB-EP008836HU1	100ug	$578		Add to Cart
BHP10505514	CSB-EP008836HU1	20ug	$306		Add to Cart

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