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Home / Proteins & Peptide

Recombinant Human Fibroblast growth factor 1(FGF1) (Active)

BHP10506928
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Email
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Subcellular Location Secreted, Cytoplasm, Cytoplasm, cell cortex, Cytoplasm, cytosol, Nucleus
Uniprot P05230
Database Links

HGNC:3665

OMIM:131220

KEGG:hsa:2246

STRING:9606.ENSP00000338548

UniGene:Hs.483635
Function Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV
Pathway Hippo signaling pathway; MAPK signaling pathway; PI3K-Akt signaling pathway; Regulation of actin cytoskeleton; Ras signaling pathway; Rap1 signaling pathway
Protein Families Heparin-binding growth factors family
Research Area Signal Transduction
Tissue Specificity Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Purity Greater than 95% as determined by SDS-PAGE.
Storage Buffer Lyophilized from a 0.2 μm Filtered 20 mM Tris, 400 mM NaCl, 1 mM DTT, pH 8.0
Immunogen Species Homo Sapiens (Human)
SKU Supplier No. Size Your price Quantity
BHP10506928 CSB-AP003761HU 1mg $1198
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BHP10506928 CSB-AP003761HU 500ug $842
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BHP10506928 CSB-AP003761HU 50ug $270
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