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Home / Proteins & Peptide

Recombinant Human Eukaryotic translation initiation factor 4E-binding protein 2(EIF4EBP2)

SKU : BHP10502286

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP007563HU
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Repressor of translation initiation involved in synaptic plasticity, learning and mory formation . Regulates EIF4E activity by preventing its assbly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation . EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal st cell renewal via its ability to repress translation initiation . Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways .
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-120aa
Mol Weight	14.9kDa
Nature	recombinant
Protein Description	Full Length

Uniprot	Q13542, Q13542
Database Links	HGNC:3289 OMIM:602224 KEGG:hsa:1979 STRING:9606.ENSP00000362314 UniGene:Hs.621200
Function	Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex
Protein Families	EIF4E-binding protein family
Research Area	Transcription
Weight	14.9kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502286	CSB-YP007563HU	1mg	$2310		Add to Cart
BHP10502286	CSB-YP007563HU	100ug	$516		Add to Cart
BHP10502286	CSB-YP007563HU	20ug	$276		Add to Cart

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