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Recombinant Human Eukaryotic translation initiation factor 3 subunit E(EIF3E)

SKU : BHP10503559

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP007534HU
Alternative Names	Eukaryotic translation initiation factor 3 subunit 6, Viral integration site protein INT-6 homolog, eIF-3 p48, Eukaryotic translation initiation factor 3 subunit 6 ; Viral integration site protein INT-6 homolog ; eIF-3 p48
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	omponent of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression . Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway . May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Eukaryotic translation initiation factor 3 subunit E; Short name= eIF3e; Alternative name(s): Eukaryotic translation initiation factor 3 subunit 6; Viral integration site protein INT-6 homolog; eIF-3 p48
Expression Region	1-445aa
Mol Weight	79.1kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm, Nucleus, PML body
Uniprot	P60228, P60228
Database Links	HGNC:3277 OMIM:602210 KEGG:hsa:3646 STRING:9606.ENSP00000220849 UniGene:Hs.405590
Function	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis
Protein Families	EIF-3 subunit E family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Ubiquitously expressed. Expressed at highest levels in appendix, lymph, pancreas, skeletal muscle, spleen and thymus.
Weight	76.795kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503559	CSB-EP007534HU	1mg	$2466		Add to Cart
BHP10503559	CSB-EP007534HU	100ug	$578		Add to Cart
BHP10503559	CSB-EP007534HU	20ug	$306		Add to Cart

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