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Recombinant Human Estradiol 17-beta-dehydrogenase 11(HSD17B11)

SKU : BHP10501454

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP843318HU
Alternative Names	17-beta-hydroxysteroid dehydrogenase 11 ,17-beta-HSD 11 ,17bHSD11 ,17betaHSD1117-beta-hydroxysteroid dehydrogenase XI ,17-beta-HSD XI ,17betaHSDXICutaneous T-cell lymphoma-associated antigen HD-CL-03 ,CTCL-associated antigen HD-CL-03Dehydrogenase/reductase SDR family member 8Retinal short-chain dehydrogenase/reductase 2 ,retSDR2Short chain dehydrogenase/reductase family 16C member 2, 17-beta-hydroxysteroid dehydrogenase 11 ; 17-beta-HSD 11 ; 17bHSD11 ; 17betaHSD1117-beta-hydroxysteroid dehydrogenase XI ; 17-beta-HSD XI ; 17betaHSDXICutaneous T-cell lymphoma-associated antigen HD-CL-03 ; CTCL-associated antigen HD-CL-03Dehydrogenase/reductase SDR family member 8Retinal short-chain dehydrogenase/reductase 2 ; retSDR2Short chain dehydrogenase/reductase family 16C member 2
Antigen	HSD17B11
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	20-300aa
Mol Weight	46.8kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Secreted
Uniprot	Q8NBQ5, Q8NBQ5
Database Links	HGNC:22960 OMIM:612831 KEGG:hsa:51170 STRING:9606.ENSP00000351035 UniGene:Hs.594923
Function	Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
Protein Families	Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily
Research Area	Metabolism
Tissue Specificity	Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in
Weight	46.8kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501454	CSB-EP843318HU	1mg	$1812		Add to Cart
BHP10501454	CSB-EP843318HU	100ug	$419		Add to Cart
BHP10501454	CSB-EP843318HU	20ug	$224		Add to Cart

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