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Home / Proteins & Peptide

Recombinant Human Ephrin type-B receptor 1(EPHB1),partial (Active)

BHP10506360
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Email
[email protected]
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Subcellular Location Cell membrane, Single-pass type I membrane protein, Early endosome membrane, Cell projection, dendrite
Uniprot P54762
Database Links

HGNC:3392

OMIM:600600

KEGG:hsa:2047

STRING:9606.ENSP00000381097

UniGene:Hs.116092
Function Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity).
Protein Families Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
Research Area Signal Transduction
Tissue Specificity Preferentially expressed in brain.
Purity Greater than 95% as determined by SDS-PAGE.
Storage Buffer Lyophilized from a 0.2 μm Filtered 20 mM Tris-HCl, 150 mM NaCl, pH 8.0
Immunogen Species Homo Sapiens (Human)
SKU Supplier No. Size Your price Quantity
BHP10506360 CSB-AP005501HU 1mg $4254
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BHP10506360 CSB-AP005501HU 500ug $2978
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BHP10506360 CSB-AP005501HU 50ug $484
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