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Home / Proteins & Peptide

Recombinant Human EphB6 Protein (His Tag)(Active)

SKU : BHP10303056

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031774
Description	The extracellular domain (Met 1-Ser 579) of human EphB6 (NP_004436.1) precursor was expressed; fused with a polyhistidine tag at the C-terminus.
Alternative Names	HEP
Reconstitution	Please refer to the printed manual for detailed information.
Background	Ephrins are divided into the ephrin-A (EFNA) class and the ephrin-B (EFNB) class based on their structures and sequence relationships. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB6 is an unusual Eph receptor; lacking catalytic capacity due to alterations in its kinase domain. Interestingly; increased metastatic activity is associated with reduced EphB6 receptor expression in several tumor types; including breast cancer. This emphasizes the potential of EphB6 to act as a suppressor of cancer aggressiveness. EphB6 suppress cancer invasiveness through c-Cbl-dependent signaling; morphologic changes; and cell attachment and indicate that EphB6 may represent a useful prognostic marker and a promising target for therapeutic approaches. EphB6 can both positively and negatively regulate cell adhesion and migration; and suggest that tyrosine phosphorylation of the receptor by an Src family kinase acts as the molecular switch for the functional transition. In addition; Ephrin-B2 may be a physiological ligand for the EphB6 receptor.
Reactivity	Human
Formulation	Lyophilized from sterile PBS; pH 7.4
Host	HEK293 Cells
Accession Number	NP_004436.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	1. Measured by its binding ability in a functional ELISA.2. Immobilized recombinant human EphB6 at 10 ug/ml (100 ul/well) can bind human EphrinB1 with a linear range of 32-800 ng/ml.3. Immobilized recombinant human EphB6 at 10 ug/ml (100 ul/well) can bind human EphrinB2 with a linear range of 1.28-32 ng/ml.
Mol Weight	61.6 kDa
Mw(kda)	61.6 kDa

Sequence Info	Met 1-Ser 579

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 92 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303056	PKSH031774	100ug	$805		Add to Cart

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