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Home / Proteins & Peptide

Recombinant Human Endonuclease 8-like 1(NEIL1)

SKU : BHP10501466

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP846619HU
Alternative Names	DNA glycosylase/AP lyase Neil1DNA-(apurinic or apyrimidinic site) lyase Neil1Endonuclease VIII-like 1FPG1Nei homolog 1 ,NEH1Nei-like protein 1, DNA glycosylase/AP lyase Neil1DNA-(apurinic or apyrimidinic site) lyase Neil1Endonuclease VIII-like 1FPG1Nei homolog 1 ; NEH1Nei-like protein 1
Antigen	NEIL1
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and roves damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the roved base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	2-390aa
Mol Weight	59.6kDa
Nature	recombinant
Protein Description	Full Length of Mature Protein

Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus, Chromosome
Uniprot	Q96FI4, Q96FI4
Database Links	HGNC:18448 OMIM:608844 KEGG:hsa:79661 STRING:9606.ENSP00000347170 UniGene:Hs.512732
Function	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U
Pathway	DNA repair pathway
Protein Families	FPG family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Ubiquitous.
Weight	59.6kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501466	CSB-EP846619HU	1mg	$1812		Add to Cart
BHP10501466	CSB-EP846619HU	100ug	$419		Add to Cart
BHP10501466	CSB-EP846619HU	20ug	$224		Add to Cart

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