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Home / Proteins & Peptide

Recombinant Human Egl nine homolog 2(EGLN2),partial

SKU : BHP10500505

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP007482HU
Alternative Names	Estrogen-induced tag 6HPH-3Hypoxia-inducible factor prolyl hydroxylase 1 ,HIF-PH1 ,HIF-prolyl hydroxylase 1 ,HPH-1,Prolyl hydroxylase domain-containing protein 1 ,PHD1, Estrogen-induced tag 6HPH-3Hypoxia-inducible factor prolyl hydroxylase 1 ; HIF-PH1 ; HIF-prolyl hydroxylase 1 ; HPH-1 ; Prolyl hydroxylase domain-containing protein 1 ; PHD1
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferencially recognized via a LXXLAP motif.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	283-407aa
Mol Weight	18.1kDa
Nature	recombinant
Protein Description	Partial

Subcellular Location	Nucleus
Uniprot	Q96KS0, Q96KS0
Database Links	HGNC:14660 OMIM:606424 KEGG:hsa:112398 STRING:9606.ENSP00000307080 UniGene:Hs.515417
Function	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferentially recognized via a LXXLAP motif.
Pathway	HIF-1 signaling pathway
Research Area	Cancer
Tissue Specificity	Expressed in adult and fetal heart, brain, liver, lung, skeletal muscle, and kidney. Also expressed in testis and placenta. Highest levels in adult brain, placenta, lung, kidney, and testis. Expressed in hormone responsive tissues, including normal and ca
Weight	18.2kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500505	CSB-EP007482HU	1mg	$1812		Add to Cart
BHP10500505	CSB-EP007482HU	100ug	$419		Add to Cart
BHP10500505	CSB-EP007482HU	20ug	$224		Add to Cart

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