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Home / Proteins & Peptide

Recombinant Human EGFR/ErbB1 Protein (aa 668-1210, His&GST Tag)(Active)

SKU : BHP10300112

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030428
Description	A DNA sequence encoding the cytoplasmic domain (Met 668-Ala 1210) of human EGFR (NP_005219) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Alternative Names	EGF R ; ErbB ; HER1 ; mENA ; ErbB1 ; PIG61
Background	As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.
Tag	His tag ; GST tag
Regulatory	RUO
Host	Baculovirus-Insect Cells
Endotoxin Level	<1.0 EU per μg protein as determined by the LAL method.
Nature	Recombinant

Shipping	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Buffer	Supplied as sterile 20 mM Tris, 500 mM NaCl, 10 % glycerol, pH 7.4
Description	Please refer to the printed manual for detailed information.
Purity	> 85 % as determined by SDS-PAGE
Expiry Date	Samples are stable for up to twelve months from date of receipt at -70℃

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10300112	PKSH030428	50ug	$717		Add to Cart

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