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Home / Proteins & Peptide

Recombinant Human E3 ubiquitin-protein ligase SMURF2(SMURF2)

SKU : BHP10501554

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP872532HU
Alternative Names	SMAD ubiquitination regulatory factor 2SMAD-specific E3 ubiquitin-protein ligase 2
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Source	E.coli
Abbreviation	SMURF2
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: E3 ubiquitin-protein ligase SMURF2; Short name= hSMURF2; EC= 6.3.2.-; Alternative name(s): SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2
Expression Region	1-748aa
Mol Weight	113.2kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Nucleus, Cytoplasm, Cell membrane, Membrane raft
Uniprot	Q9HAU4, Q9HAU4
Database Links	HGNC:16809 OMIM:605532 KEGG:hsa:64750 STRING:9606.ENSP00000262435 UniGene:Hs.515011
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Pathway	Hedgehog signaling pathway; TGF-beta signaling pathway; Endocytosis
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Widely expressed.
Weight	113.54kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501554	CSB-EP872532HU	1mg	$1812		Add to Cart
BHP10501554	CSB-EP872532HU	100ug	$419		Add to Cart
BHP10501554	CSB-EP872532HU	20ug	$224		Add to Cart

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