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Home / Proteins & Peptide

Recombinant Human DNA repair protein RAD51 homolog 4(RAD51D)

SKU : BHP10503549

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP019268HU
Alternative Names	R51H3, RAD51 homolog D, RAD51-like protein 3, TRAD, R51H3 ; RAD51 homolog D ; RAD51-like protein 3 ; TRAD
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: DNA repair protein RAD51 homolog 4; Alternative name(s): R51H3; RAD51 homolog D; RAD51-like protein 3; TRAD
Expression Region	1-328aa
Mol Weight	62.0kDa
Nature	recombinant
Protein Description	Full Length

Involvement In Disease	Breast-ovarian cancer, familial, 4 (BROVCA4)
Subcellular Location	Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Chromosome, telomere
Uniprot	O75771, O75771
Database Links	HGNC:9823 OMIM:602954 KEGG:hsa:5892 STRING:9606.ENSP00000466834 UniGene:Hs.631757
Function	Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2
Protein Families	RecA family, RAD51 subfamily
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed in leukocytes.
Weight	63.808kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503549	CSB-EP019268HU	1mg	$2466		Add to Cart
BHP10503549	CSB-EP019268HU	100ug	$578		Add to Cart
BHP10503549	CSB-EP019268HU	20ug	$306		Add to Cart

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