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Home / Proteins & Peptide

Recombinant Human DNA-directed RNA polymerase III subunit RPC3(POLR3C)

SKU : BHP10501551

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP871578HU
Alternative Names	DNA-directed RNA polymerase III subunit CRNA polymerase III 62 kDa subunit ,RPC62, DNA-directed RNA polymerase III subunit CRNA polymerase III 62 kDa subunit ; RPC62
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other mbers of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as tplate for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-534aa
Mol Weight	76.6kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Nucleus
Uniprot	Q9BUI4, Q9BUI4
Database Links	HGNC:30076 OMIM:617454 KEGG:hsa:10623 STRING:9606.ENSP00000334564 UniGene:Hs.515768
Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner
Protein Families	Eukaryotic RPC3/POLR3C RNA polymerase subunit family
Research Area	Epigenetics and Nuclear Signaling
Weight	76.6kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501551	CSB-EP871578HU	1mg	$1812		Add to Cart
BHP10501551	CSB-EP871578HU	100ug	$419		Add to Cart
BHP10501551	CSB-EP871578HU	20ug	$224		Add to Cart

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