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Home / Proteins & Peptide

Recombinant Human Dickkopf-related protein 1(DKK1),partial

SKU : BHP10504287

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP006920HU
Description	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmbrane protein KREN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Alternative Names	SK
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Dickkopf-related protein 1 Short name= Dickkopf-1 Short name= Dkk-1 Short name= hDkk-1Alternative name(s): SK
Expression Region	33-266
Nature	Recombinant
Protein Description	Partial

Subcellular Location	Secreted
Uniprot	O94907, O94907
Database Links	HGNC:2891 OMIM:605189 KEGG:hsa:22943 STRING:9606.ENSP00000363081 UniGene:Hs.40499
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6
Pathway	Wnt signaling pathway
Protein Families	Dickkopf family
Tissue Specificity	Placenta.
Weight	29.7 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	>85% (SDS-PAGE)
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10504287	CSB-EP006920HU	1mg	$1812		Add to Cart
BHP10504287	CSB-EP006920HU	100ug	$419		Add to Cart
BHP10504287	CSB-EP006920HU	20ug	$224		Add to Cart

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