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Recombinant Human Deoxyguanosine kinase, mitochondrial(DGUOK)

BHP10501312
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Involvement In Disease Mitochondrial DNA depletion syndrome 3 (MTDPS3); Portal hypertension, non-cirrhotic (NCPH); Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 (PEOB4)
Subcellular Location Mitochondrion
Uniprot Q16854, Q16854
Database Links

HGNC:2858

OMIM:251880

KEGG:hsa:1716

STRING:9606.ENSP00000264093

UniGene:Hs.469022
Function Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents.
Protein Families DCK/DGK family
Research Area Signal Transduction
Tissue Specificity Ubiquitous. Highest expression in muscle, brain, liver and lymphoid tissues.
Weight 43.9kDa
Stotage Note Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer Tris-based buffer，50% glycerol
Purity Greater than 90% as determined by SDS-PAGE.
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer Tris-based buffer,50% glycerol
Immunogen Species Homo Sapiens (Human)
SKU Supplier No. Size Your price Quantity
BHP10501312 CSB-EP621974HU 1mg $1812
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BHP10501312 CSB-EP621974HU 100ug $419
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BHP10501312 CSB-EP621974HU 20ug $224
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