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Home / Proteins & Peptide

Recombinant Human DENN domain-containing protein 1A(DENND1A)

SKU : BHP10504249

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP823472HU
Description	Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles.
Alternative Names	Connecdenn 1 ,Connecdenn,Protein FAM31A, Connecdenn 1 ; Connecdenn ; Protein FAM31A
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-559aa
Mol Weight	79.4kDa
Nature	Recombinant
Protein Description	Full Length of Isoform 2

Involvement In Disease	Genetic variants in DENND1A may play a role in susceptibility to polycystic ovary syndrome (PCOS), the most common endocrine disease among premenopausal women. PCOS is a complex disorder characterized by infertility, hirsutism, obesity, various menstrual disturbances, and enlarged ovaries studded with atretic follicles.
Subcellular Location	Cytoplasmic vesicle, clathrin-coated vesicle membrane, Peripheral membrane protein, Cell junction, synapse, presynaptic cell membrane
Uniprot	Q8TEH3, Q8TEH3
Database Links	HGNC:29324 OMIM:613633 KEGG:hsa:57706 STRING:9606.ENSP00000362727 UniGene:Hs.744995
Function	Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes
Research Area	Neuroscience
Weight	79.4 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10504249	CSB-EP823472HU	1mg	$1812		Add to Cart
BHP10504249	CSB-EP823472HU	100ug	$419		Add to Cart
BHP10504249	CSB-EP823472HU	20ug	$224		Add to Cart

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