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Recombinant Human Dehydrogenase/reductase SDR family member 2, mitochondrial(DHRS2)

SKU : BHP10503558

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP615674HU
Alternative Names	Dicarbonyl reductase HEP27, Protein D, Short chain dehydrogenase/reductase family 25C member 1, Dicarbonyl reductase HEP27 ; Protein D ; Short chain dehydrogenase/reductase family 25C member 1
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Source	E.coli
Abbreviation	DHRS2
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Dehydrogenase/reductase SDR family member 2 EC= 1.1.1.-Alteative name(s): Dicarbonyl reductase HEP27 Protein D
Expression Region	1-300aa
Mol Weight	58.5kDa
Nature	recombinant
Protein Description	Full Length of Isoform 2

Subcellular Location	Mitochondrion matrix, Nucleus
Uniprot	Q13268, Q13268
Database Links	HGNC:18349 OMIM:615194 KEGG:hsa:10202 STRING:9606.ENSP00000344674 UniGene:Hs.272499
Function	Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Protein Families	Short-chain dehydrogenases/reductases (SDR) family
Research Area	Signal Transduction
Tissue Specificity	Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes.
Weight	60.7kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503558	CSB-EP615674HU	1mg	$2466		Add to Cart
BHP10503558	CSB-EP615674HU	100ug	$578		Add to Cart
BHP10503558	CSB-EP615674HU	20ug	$306		Add to Cart

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