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Home / Proteins & Peptide

Recombinant Human Decorin/DCN Protein (Fc Tag)

SKU : BHP10303057

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031779
Description	A DNA sequence encoding the mature form of human Decorin (NP_001911.1) (Asp 31-Lys 359) was expressed with the fused Fc region of human IgG1 at the N-terminus.
Alternative Names	CSCD;DSPG2;PG40;PGII;PGS2;SLRR1B
Reconstitution	Please refer to the printed manual for detailed information.
Background	Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.
Reactivity	Human
Tag	N-Fc
Formulation	Lyophilized from sterile PBS, pH 7.4
Host	HEK293 Cells
Accession Number	NP_001911.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	63. kDa
Mw(kda)	63. kDa

Sequence Info	Asp 31-Lys 359

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303057	PKSH031779	100ug	$454		Add to Cart

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