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Recombinant Human Cytochrome b-245 heavy chain(CYBB),partial

SKU : BHP10504957

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP006325HU1
Description	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Alternative Names	CGD91-phox, Cytochrome b(558) subunit beta, CGD91-phox Cytochrome b(558) subunit beta
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H+ currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	283-570aa
Mol Weight	37.2kDa
Nature	Recombinant
Protein Description	Partial

Involvement In Disease	Granulomatous disease, chronic, X-linked (CGD); Immunodeficiency 34 (IMD34)
Subcellular Location	Cell membrane, Multi-pass membrane protein
Uniprot	P04839, P04839
Database Links	HGNC:2578 OMIM:300481 KEGG:hsa:1536 STRING:9606.ENSP00000367851 UniGene:Hs.292356
Function	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Pathway	HIF-1 signaling pathway; Necroptosis; Leukocyte transendothelial migration; NOD-like receptor signaling pathway; AGE-RAGE signaling pathway in diabetic complications
Research Area	Immunology
Tissue Specificity	Detected in neutrophils (at protein level).
Weight	37.2 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10504957	CSB-EP006325HU1	1mg	$1812		Add to Cart
BHP10504957	CSB-EP006325HU1	100ug	$419		Add to Cart
BHP10504957	CSB-EP006325HU1	20ug	$224		Add to Cart

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