Recombinant Human Cysteine and glycine-rich protein 3(CSRP3)

Mfr.No.	CSB-EP006087HU
Alternative Names	Cardiac LIM protein,Cysteine-rich protein 3 ,CRP3LIM domain protein, cardiacMuscle LIM protein, Cardiac LIM protein ; Cysteine-rich protein 3 ; CRP3LIM domain protein, cardiacMuscle LIM protein
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assbly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation .
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-194aa
Mol Weight	37.0kDa
Nature	recombinant
Protein Description	Full Length

Involvement In Disease	Cardiomyopathy, dilated 1M (CMD1M); Cardiomyopathy, familial hypertrophic 12 (CMH12)
Subcellular Location	Nucleus, Cytoplasm, Cytoplasm, cytoskeleton, Cytoplasm, myofibril, sarcomere, Z line, Cytoplasm, myofibril, sarcomere
Uniprot	P50461, P50461
Database Links	HGNC:2472 OMIM:600824 KEGG:hsa:8048 STRING:9606.ENSP00000265968 UniGene:Hs.83577
Function	Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1
Research Area	Developmental Biology
Tissue Specificity	Cardiac and slow-twitch skeletal muscles. Isoform 2 is expressed in striated muscle. Isoform 2 is specifically expressed at higher levels in patients with neuromuscular diseases, such as limb-girdle muscular dystrophy 2A (LGMD2A), Duchenne muscular dystro
Weight	37kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol