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Home / Proteins & Peptide

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 2(CREB3L2)

SKU : BHP10503645

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP754617HU
Alternative Names	BBF2 human homolog on chromosome 7
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-247aa
Mol Weight	54.6kDa
Nature	recombinant
Protein Description	Full Length of BC063666

Involvement In Disease	A chromosomal aberration involving CREB3L2 is found in low grade fibromyxoid sarcoma (LGFMS). Translocation t(7;16)(q33;p11) with FUS.
Subcellular Location	Endoplasmic reticulum membrane, Single-pass type II membrane protein, Note=ER membrane resident protein, Upon ER stress, translocated to the Golgi apparatus where it is cleaved, The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus, SUBCELLULAR LOCATION: Processed cyclic AMP-responsive element-binding protein 3-like protein 2: Nucleus
Uniprot	Q70SY1, Q70SY1
Database Links	HGNC:23720 OMIM:608834 KEGG:hsa:64764 STRING:9606.ENSP00000329140 UniGene:Hs.490273
Function	Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death
Pathway	cAMP signaling pathway; Estrogen signaling pathway; Melanogenesis; PI3K-Akt signaling pathway; TNF signaling pathway; Th17 cell differentiation; Thyroid hormone synthesis; AMPK signaling; cGMP-PKG signaling pathway; Glucagon signaling pathway
Protein Families	BZIP family, ATF subfamily
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart.
Weight	54.817kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503645	CSB-EP754617HU	1mg	$1812		Add to Cart
BHP10503645	CSB-EP754617HU	100ug	$419		Add to Cart
BHP10503645	CSB-EP754617HU	20ug	$224		Add to Cart

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