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Home / Proteins & Peptide

Recombinant Human Core-binding factor subunit beta(CBFB)

SKU : BHP10501323

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP623835HU
Alternative Names	Polyomavirus enhancer-binding protein 2 beta subunit ,PEA2-beta ,PEBP2-beta,SL3-3 enhancer factor 1 subunit beta,SL3/AKV core-binding factor beta subunit, Polyomavirus enhancer-binding protein 2 beta subunit ; PEA2-beta ; PEBP2-beta ; SL3-3 enhancer factor 1 subunit beta ; SL3/AKV core-binding factor beta subunit
Tag	N-terminal 6xHis-SUMO-tagged
Regulatory	RUO
Relevance	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-182aa
Mol Weight	37.5kDa
Nature	recombinant
Protein Description	Full Length

Involvement In Disease	A chromosomal aberration involving CBFB is associated with acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein that consists of the 165 N-terminal residues of CBF-beta (PEPB2) with the tail region of MYH11.
Subcellular Location	Nucleus
Uniprot	Q13951, Q13951
Database Links	HGNC:1539 OMIM:121360 KEGG:hsa:865 STRING:9606.ENSP00000415151 UniGene:Hs.460988
Function	CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBFB enhances DNA binding by RUNX1.
Protein Families	CBF-beta family
Research Area	Epigenetics and Nuclear Signaling
Weight	37.49kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10501323	CSB-EP623835HU	1mg	$1812		Add to Cart
BHP10501323	CSB-EP623835HU	100ug	$419		Add to Cart
BHP10501323	CSB-EP623835HU	20ug	$224		Add to Cart

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