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Home / Proteins & Peptide

Recombinant Human Collagen alpha-3(IV) chain(COL4A3),partial

SKU : BHP10500438

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP005743HU
Alternative Names	Goodpasture antigen
Antigen	COL4A3
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Type IV collagen is the major structural component of glomerular basent mbranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.Tumstatin, a cleavage fragment corresponding to the collagen alpha 3(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity; these two anti-tumor properties may be regulated via RGD-independent ITGB3-mediated mechanisms.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1427-1668aa
Mol Weight	30.6 kDa
Nature	recombinant
Protein Description	Partial

Involvement In Disease	Alport syndrome, autosomal recessive (APSAR); Hematuria, benign familial (BFH); Alport syndrome, autosomal dominant (APSAD)
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane
Uniprot	Q01955, Q01955
Database Links	HGNC:2204 OMIM:104200 KEGG:hsa:1285 STRING:9606.ENSP00000379823 UniGene:Hs.570065
Function	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.; FUNCTION
Pathway	PI3K-Akt signaling pathway; Focal adhesion; AGE-RAGE signaling pathway in diabetic complications
Protein Families	Type IV collagen family
Research Area	Cell Adhesion
Tissue Specificity	Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression
Weight	30.6kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500438	CSB-EP005743HU	1mg	$1812		Add to Cart
BHP10500438	CSB-EP005743HU	100ug	$419		Add to Cart
BHP10500438	CSB-EP005743HU	20ug	$224		Add to Cart

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