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Home / Proteins & Peptide

Recombinant Human Chromobox protein homolog 7(CBX7)

SKU : BHP10500391

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP004603HU
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin rodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Source	E.coli
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	1-251aa
Mol Weight	32.3kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Nucleus
Uniprot	O95931, O95931
Database Links	HGNC:1557 OMIM:608457 KEGG:hsa:23492 STRING:9606.ENSP00000216133 UniGene:Hs.356416
Function	Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
Research Area	Transcription
Weight	32.4kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10500391	CSB-EP004603HU	1mg	$1812		Add to Cart
BHP10500391	CSB-EP004603HU	100ug	$419		Add to Cart
BHP10500391	CSB-EP004603HU	20ug	$224		Add to Cart

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