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Home / Proteins & Peptide

Recombinant Human Centromere protein K(CENPK)

SKU : BHP10503821

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-EP005214HU
Alternative Names	Interphase centromere complex protein 37, Protein AF-5alpha, p33, Interphase centromere complex protein 37 ; Protein AF-5alpha ; p33
Tag	N-terminal GST-tagged
Regulatory	RUO
Relevance	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore.
Source	E.coli
Abbreviation	CENPK
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Centromere protein K; Short name= CENP-K; Alternative name(s): Interphase centromere complex protein 37; Protein AF-5alpha; p33
Expression Region	1-269aa
Mol Weight	58.7kDa
Nature	recombinant
Protein Description	Full Length

Involvement In Disease	Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.
Subcellular Location	Nucleus, Chromosome, centromere, Chromosome, centromere, kinetochore
Uniprot	Q9BS16, Q9BS16
Database Links	HGNC:29479 OMIM:611502 KEGG:hsa:64105 STRING:9606.ENSP00000242872 UniGene:Hs.529778
Function	Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.
Protein Families	CENP-K/MCM22 family
Research Area	Epigenetics and Nuclear Signaling
Tissue Specificity	Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.
Weight	57.259kD

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10503821	CSB-EP005214HU	1mg	$2466		Add to Cart
BHP10503821	CSB-EP005214HU	100ug	$578		Add to Cart
BHP10503821	CSB-EP005214HU	20ug	$306		Add to Cart

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