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Home / Proteins & Peptide

Recombinant Human CDK6/CyclinD3 (N-His tag)

SKU : BHP10901141

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z500076
Description	CDK6 is a member of the cyclin-dependent family of protein kinases that are important regulators of cell cycle progression. CDK6 activity is regulated by the D-type cyclins and members of the INK4 family of CDK inhibitors . The CDK6 kinase activity is detected in mid-G1 phase of the cell cycle and is responsible for the phosphorylation and regulation of the activity of tumor suppressor protein Rb. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivities in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein .
Alternative Names	PLSTIRE ; MGC59692 /CCND3
Tag	N-His tag
Quantity	10 µg
Regulatory	RUO
Source	Insect cells
Host	Human
Biological Activity Comment	The specific activity of CDK6/CyclinD3 was determined to be 36 nmol/min/mgas per activity assay protocol using protein substrate Rb (773-928).

Weight	35.0 kDa, 40.0 kDa

Format	Liquid 50mM NaPhosphate, pH7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.2mM DTT, 25% glycerol.
Purity	70% - 90%
Storage	Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10901141	Z500076	10µg	$361.11		Add to Cart

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