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Home / Proteins & Peptide

Recombinant Human CDC37/CDC37A Protein (GST Tag)

SKU : BHP10302985

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031497
Description	A DNA sequence encoding the full length of human CDC37 (NP_008996.1) (Met 1-Val 378) was fused with the GST tag at the C-terminus.
Alternative Names	P50CDC37
Reconstitution	Please refer to the printed manual for detailed information.
Background	CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.
Reactivity	Human
Tag	C-GST
Formulation	Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM GSH, 0.5mM PMSF, 10% glycerol, pH 7.4
Host	Baculovirus-Insect Cells
Accession Number	NP_008996.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	70.7 kDa
Mw(kda)	70.7 kDa

Sequence Info	Met 1-Val 378

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 85 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302985	PKSH031497	50ug	$732		Add to Cart

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