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Home / Proteins & Peptide

Recombinant Human CD27/TNFRSF7 Protein (Fc Tag)(Active)

SKU : BHP10303087

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031924
Description	A DNA sequence encoding the human CD27 (P26842) (Met1-Ile192) was expressed; fused with the Fc region of rabbit IgG at the C-terminus.
Alternative Names	S152;S152. LPFS2;S152.LPFS2;T14;TNFRSF7;Tp55
Reconstitution	Please refer to the printed manual for detailed information.
Background	CD27; also known as TNFRSF7; is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage; and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer; CD27 has been shown to play roles in lymphoid proliferation; differentiation; and apoptosis.It has important role in generation of T cell immunity; and is an apparently robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule; the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity; and meanwhile; plays a key role in regulating B-cell differentiation; activation and immunoglobulin synthesis.Immune CheckpointImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IHC Antibodies Immune Checkpoint Detection: ICC Antibodies Immune Checkpoint Detection: FCM AntibodiesImmune Checkpoint ProteinsImmune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
Reactivity	Human
Tag	C-Fc
Formulation	Lyophilized from sterile PBS; pH 7.4
Host	HEK293 Cells
Accession Number	P26842
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Bioactivity	Measured by its binding ability in a functional ELISA.Immobilized human CD27-his at 10 ug/mL (100 ul/well) can bind biotinylated human CD70-Fc; The EC50 of biotinylated human CD70-Fc is 95-150 ng/mL.
Mol Weight	44.4 kDa
Mw(kda)	44.4 kDa

Sequence Info	Met 1-Ile192

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 95 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303087	PKSH031924	200ug	$1210		Add to Cart

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