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Home / Proteins & Peptide

Recombinant Human CD20/MS4A1 Protein (aa 213-297, His Tag)

SKU : BHP10302929

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031312
Description	A DNA sequence encoding the human CD20 (NP_068769.2) (Glu213-Pro297) was expressed; with an N-terminal polyhistidine tag.
Alternative Names	B1;Bp35;CD20;CVID5;LEU-16;MS4A1;MS4A2;S7
Reconstitution	Please refer to the printed manual for detailed information.
Background	CD20 (membrane-spanning 4-domains; subfamily A; member 1); also known as MS4A1; is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed on all stages of B cell development except the first and last. CD20 / MS4A1 is present from pre-pre B cells through memory cells; but not on either pro-B cells or plasma cells. It is a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5(CVID5). CVID5 is a primary immunodeficiency characterized by antibody deficiency; hypogammaglobulinemia; recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range; but can be low.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Reactivity	Human
Tag	N-His
Formulation	Lyophilized from sterile PBS; pH 7.4
Host	HEK293 Cells
Accession Number	NP_068769.2
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	12.1 kDa
Mw(kda)	12.1 kDa

Sequence Info	Glu213-Pro297

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 83 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302929	PKSH031312	20ug	$612		Add to Cart

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