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Home / Proteins & Peptide

Recombinant Human Cathepsin A/CTSA Protein (His Tag)

SKU : BHP10303009

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH031576
Description	A DNA sequence encoding the human cathepsin A isoform b (Met 1-Tyr 480) (NP_001121167.1) was expressed with a N-terminal signal peptide and a C-terminal polyhistidine tag.
Alternative Names	Lysosomal protective protein;CTSA;Carboxypeptidase C;Carboxypeptidase L;Cathepsin A;GLB2;GSL;NGBE;PPCA;PPGB
Reconstitution	Please refer to the printed manual for detailed information.
Background	Lysosomal carboxypeptidase, cathepsin A (protective protein, CathA), is a component of the lysosomal multienzyme complex along with beta-galactosidase (GAL) and sialidase Neu1, where it activates Neu1 and protects GAL and Neu1 against the rapid proteolytic degradation. Cathepsin A is a multicatalytic enzyme with deamidase and esterase in addition to carboxypeptidase activities. It was recently identified in human platelets as deamidase. In vitro, it hydrolyzes a variety of bioactive peptide hormones including tachykinins, suggesting that extralysosomal cathepsin A plays a role in regulation of bioactive peptide functions. It is a member of the alpha/beta hydrolase fold family and has been suggested to share a common ancestral relationship with other alpha/beta hydrolase fold enzymes, such as cholinesterases. Cathepsin A defects are linked to multiple forms of Galactosialidosis with a combined secondary deficiency of beta-galactosidase and neuraminidase. Cathepsin A is a key molecule in the onset of galactosialidosis and also highlight the therapeutic acts in vivo as an endothelin-1-inactivating enzyme and strongly confirm a crucial role of this enzyme in effective elastic fiber formation.
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile 25mM Tris, 0.15mM NaCl, pH 7.5
Host	HEK293 Cells
Accession Number	NP_001121167.1
Endotoxin Level	< 1.0 EU per ug as determined by the LAL method.
Mol Weight	53 kDa
Mw(kda)	53 kDa

Sequence Info	Met 1-Tyr 480

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 90 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10303009	PKSH031576	50ug	$867		Add to Cart

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