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Home / Proteins & Peptide

Recombinant Human Casein kinase I isoform epsilon(CSNK1E)

SKU : BHP10502265

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-YP006068HU
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phospohorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
Source	Yeast
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Protein Name	Recommended name: Casein kinase I isoform epsilon; Short name= CKI-epsilon; Short name= CKIe; EC= 2.7.11.1
Expression Region	1-416aa
Mol Weight	49.3kDa
Nature	recombinant
Protein Description	Full Length

Subcellular Location	Cytoplasm, Nucleus
Uniprot	P49674, P49674
Database Links	HGNC:2453 OMIM:600863 KEGG:hsa:102800317 STRING:9606.ENSP00000352929 UniGene:Hs.474833
Function	Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.
Protein Families	Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily
Research Area	Signal Transduction
Tissue Specificity	Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.
Weight	49.3kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10502265	CSB-YP006068HU	500ug	$1298		Add to Cart
BHP10502265	CSB-YP006068HU	100ug	$470		Add to Cart
BHP10502265	CSB-YP006068HU	20ug	$250		Add to Cart

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