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Home / Proteins & Peptide

Recombinant Human Carbonic Anhydrase 5B/CA5B Protein (His Tag)(Active)

SKU : BHP10302832

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Elabscience Biotechnology Co.,Ltd

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Mfr.No.	PKSH030856
Description	A DNA sequence encoding the mature form of human CA5B (Q9Y2D0) (Cys 34-Pro 317) was fused with a polyhistidine tag at the C-terminus and an initial Met at the N-terminus.
Alternative Names	Carbonic Anhydrase 5B Mitochondrial; Carbonate Dehydratase VB; Carbonic Anhydrase VB; CA-VB; CA5B
Reconstitution	Please refer to the printed manual for detailed information.
Background	Carbonic anhydrase 5B; also known as carbonate dehydratase VB; carbonic anhydrase VB; CA-VB and CA5B; is a member of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart; pancreas; kidney; placenta; lung; and skeletal muscle. It is not expressed in liver. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes; including respiration; calcification; acid-base balance; bone resorption; and the formation of aqueous humor; cerebrospinal fluid; saliva; and gastric acid. CAs show extensive diversity in tissue distribution and in their subcellular localization. CA5B / CA-VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA5A / CA-VA. CA5B / CA-VB has a wider tissue distribution than CA5A / CA-VA; which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. CA5A / CA-VA is activated by histamine; L-adrenaline; L- and D-histidine; and L- and D-phenylalanine. It is inhibited by coumarins; sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt). CA5B / CA-VB is inhibited by coumarins; sulfonamide derivatives such as acetazolamide (AZA); saccharin and Foscarnet (phosphonoformate trisodium salt).
Reactivity	Human
Tag	C-His
Formulation	Lyophilized from sterile 20mM Tris; 50mM NaCl; 0.05% Brij-35; pH 8.0
Host	E.coli
Accession Number	Q9Y2D0
Endotoxin Level	Please contact us for more information.
Bioactivity	Measured by its esterase activity. The specific activity is >150 pmoles/min/ug.
Mol Weight	34 kDa
Mw(kda)	34 kDa

Sequence Info	Cys 34-Pro 317

Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Stotage Note	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Purity	> 97 % as determined by reducing SDS-PAGE.

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHP10302832	PKSH030856	50ug	$721		Add to Cart

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