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Home / Proteins & Peptide

Recombinant Human C-type lectin domain family 4 member C (CLEC4C) ,partial

SKU : BHP10505759

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-MP855470HU
Description	Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.
Alternative Names	Blood dendritic cell antigen 2, BDCA-2, C-type lectin superfamily member 7, Dendritic lectin, CD_antigen: CD303, Blood dendritic cell antigen 2 Short name: BDCA-2 C-type lectin superfamily member 7 Dendritic lectin CD_antigen: CD303
Tag	N-terminal 6xHis-tagged
Regulatory	RUO
Relevance	Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.
Source	Mammalian cell
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Expression Region	45-213aa
Mol Weight	24.0kDa
Nature	Recombinant
Protein Description	Partial

Subcellular Location	Cell membrane, Single-pass type II membrane protein
Uniprot	Q8WTT0, Q8WTT0
Database Links	HGNC:13258 OMIM:606677 KEGG:hsa:170482 STRING:9606.ENSP00000353500 UniGene:Hs.351812
Function	Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells
Research Area	Immunology
Tissue Specificity	Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.
Weight	24 kDa

Stotage Note	Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
Buffer	Tris-based buffer，50% glycerol
Purity	Greater than 90% as determined by SDS-PAGE.
Storage	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Storage Buffer	Tris-based buffer,50% glycerol

Immunogen Species	Homo Sapiens (Human)

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SKU	Supplier No.	Size	Your price	Quantity
BHP10505759	CSB-MP855470HU	500ug	$3696		Add to Cart
BHP10505759	CSB-MP855470HU	100ug	$1232		Add to Cart
BHP10505759	CSB-MP855470HU	20ug	$440		Add to Cart

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