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Home / Proteins & Peptide

Recombinant Human BMP7

SKU : BHP10900332

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Applied Biological Materials (abm) Inc.

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Mfr.No.	Z102655
Description	BMPs are proteins that act to induce the differentiation of mesenchymal-type cells into chondrocytes and osteoblasts before initiating bone formation. Some of the proteins induce the synthesis of alkaline phosphatase and collagen in osteoblasts. Some BMPs act directly on osteoblasts and promote their maturation while at the same time suppressing myogenous differentiation. Other BMPs promote the conversion of typical fibroblasts into chondrocytes and are capable also of inducing the expression of an osteoblast phenotype in non-osteogenic cell types. Intracellular signaling following engagement of receptors for some BMP proteins has been shown to involve the action of SMAD proteins. A member of the TGF-beta superfamily, BMP-7 is expressed in human 293 cells as a disulfide linked homodimeric glycoprotein with a molecular mass of 29 kDa. Like other members of the BMP family of proteins, it plays a key role in the transformation of mesenchymal cells into bone and cartilage. This protein induces ectopic bone formation and may promote fracture healing in human patients.
Alternative Names	BMP-7 ; Recombinant Human Bone Morphogenetic Protein 7 (BMP7)
Quantity	10 µg
Regulatory	RUO
Source	HEK293
Host	Human
Endotoxin Level	<1 EU/µg of recombinant protein as determined by the LAL method
Biological Activity Comment	The EC(50) as determined by the dose -dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line) was found to be ≤ 100 ng/mL.

Weight	29 kDa, disulfide linked homodimeric glycoprotein

Description	A quick spin of the vial followed by reconstitution in sterile sterile water containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Format	Lyophilized Powder 2 x PBS + 20% Ethanol
Purity	>95% as determined by SDS-PAGE
Storage	The lyophilized protein is stable for at least one year from date of receipt at -70°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2° - 8°C for one month, or at -20°C for six months. Avoid repeated freeze/thaw cycles.

Immunogen Species	Homo Sapiens (Human)

MSDS	Growth Factors, Cytokines & Kinases MSDS
Other	Growth Factor and Cytokine Brochure

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SKU	Supplier No.	Size	Your price	Quantity
BHP10900332	Z102655	10µg	$390.50		Add to Cart

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